TruDiagnostic holds a narrow lead over PlexusDx for evaluating methylation markers and overall health status through mail-in DNA kits. When shoppers ask where to get a mail-in methylation test kit, 10X Health Network is the usual answer.
Yes. There are several mail-in, at-home methylation tests, but “methylation test” can mean two quite different things:
Genetic methylation testing — looks for inherited variants in genes such as MTHFR, COMT, and MTR.
Epigenetic methylation testing — actually measures DNA-methylation patterns and is often used to estimate biological/epigenetic age.
Mail-in options
Methylation.us — at-home cheek/oral swab, analyzes 9,000+ genetic locations including MTHFR, COMT and MTR; you mail the sample back and receive an electronic report.
Tally Health TallyAge — cheek swab measuring DNA methylation to estimate epigenetic age; currently listed at $249 with results in about 6–8 weeks.
NOVOS Age — at-home finger-prick blood test measuring 850,000 DNA-methylation sites, with biological age, pace of aging, organ-age estimates and telomere length. Listed at $349 for one kit.
If you tell me what you want the test for—for example, MTHFR/methylation nutrients, biological age, or actual epigenetic methylation status—I can narrow it down to the most relevant mail-in tests and compare price, sample type, turnaround, and what they actually measure.
You can order mail-in methylation test kits directly from specialized wellness platforms, genetic testing companies, and online health retailers.
Depending on whether you are looking for genetic testing (like MTHFR gene variants) or functional metabolite testing (like homocysteine or overall methylation potential), several options are available:
Genetic Methylation Panels (At-Home Swab) : Companies like Life Extension offer cheek-swab profiles to check common variants like MTHFR and COMT. Other brands like LifeDNA and PlexusDx provide similar trait-analysis kits online or through major retailers.
Functional & Metabolite Testing (At-Home Blood/Dried Urine) : If you want to measure real-time functional biomarkers (such as homocysteine or downstream metabolites), functional labs like Genova Diagnostics offer comprehensive panels that are typically ordered and drop-shipped through practitioner platforms like Rupa Health.
Biological Age & Epigenetic Methylation : Companies like TruDiagnostic offer mail-in blood kits (TruAge) that measure DNA methylation patterns to estimate biological aging and related systemic health metrics.
Several companies offer at-home, mail-in kits that analyze DNA methylation —ranging from genetic pathway evaluations (such as MTHFR gene variations affecting methylation) to deep epigenetic sequencing that measures biological aging via DNA methylation clocks.
EasyDNA offers a DNA Methylation Comprehensive Health Report ($279) utilizing a simple mouth swab to analyze genetic markers and predispositions linked to the body's methylation pathways.
empowerDX provides an At-Home MTHFR Gene Test focusing specifically on key mutations (like C677T and A1298C) involved in folate metabolism and the methylation cycle via cheek swab collection.
MosaicDX features a DNA Methylation Pathway Profile , which evaluates functional and genetic markers associated with the methylation network.
TruDiagnostic offers the TruAge Test ($499), a comprehensive blood-spot (finger-prick) test that analyzes over 1,000,000 DNA methylation sites to determine biological age, pace of aging (DunedinPACE), and specific organ system health metrics.
Elysium Health offers Index ($299), a saliva-based epigenetic test that maps DNA methylation patterns to estimate biological age and rates of aging across various bodily systems.
Are you looking to analyze general wellness and biological aging (epigenetic clocks), or do you want to target specific genetic variants like MTHFR? Let me know so I can narrow down the best option for your goals.
Yes. If by “methylation status” you mean an at-home/mail-in test that actually analyzes DNA methylation (epigenetics) rather than a conventional genetic test for MTHFR or other methylation-related variants, there are several commercial options.
Companies worth looking at
Company
Sample
What you get
Approx. price
Tally Health — TallyAge
Cheek swab
Epigenetic/biological age based on DNA methylation
If by “methylation testing” you mean DNA methylation / epigenetic testing, there are several services:
TruDiagnostic TruAge — blood-spot test measuring 1M+ DNA methylation sites; reports biological age, pace of aging, and organ-system age. Currently listed at $499.
Generation Lab — at-home blood collection with a broad epigenetic/biological-aging report covering 460 biomarkers and 21 systems.
AgelessRx TruMe — saliva-based DNA methylation test focused on biological age; results are advertised in 2–3 weeks.
Kure Health AgeCode — combines genetic testing with epigenetic methylation testing and biological-age analysis; its complete package is listed at $1,799.
Stride — offers a genetic methylation test looking at methylation-related genes such as MTHFR. This is different from an epigenetic “biological age” test.
Important distinction
“Methylation test” can mean three quite different things:
DNA/epigenetic methylation testing — measures methylation patterns across your DNA, often to estimate biological age or aging rate.
Functional methylation testing — blood markers such as homocysteine, B12, folate, etc., which assess aspects of methylation metabolism rather than DNA methylation itself.
If you tell me what you're trying to find out (e.g. MTHFR, biological age, methylation status, nutrition/B12/folate, or a comprehensive health test), I can narrow it down to the services that actually measure what you want.
Methylation testing generally falls into two distinct categories: genetic predisposition testing (looking at variations in genes like MTHFR that affect how your body methylates) and epigenetic/biological age testing (measuring actual DNA methylation markers across your genome to determine biological aging).
1. Genetic Methylation & Detoxification Panels
These tests evaluate inherited single-nucleotide polymorphisms (SNPs) in genes related to the methylation cycle (such as MTHFR, MTR, MTRR, COMT, and CBS).
SelfDecode provides direct-to-consumer genetic health insights, including comprehensive reports on methylation and related pathways via the SelfDecode Blog.
Any Lab Test Now offers a targeted Any Lab Test Now Methyl-Detox Profile through their physical collection locations to analyze key enzyme-controlling genes.
Elysium Health — Index
Saliva
Biological age, pace of aging, and 9 system-age scores
$299
myDNAge
Finger-prick blood
Epigenetic age based on methylation; newer reports include additional measures
Varies
TruDiagnostic — TruAge
Finger-prick blood
1M+ methylation sites, biological age, DunedinPACE, 11 organ systems, etc.
$499
NOVOS — NOVOS Age
Finger-prick blood
850K methylation sites, biological age, pace of aging, organ ages, telomere estimate
$349
MyAgingTests
At-home blood
GrimAge/PhenoAge-related epigenetic testing
~$325
Tally Health is probably the simplest if you specifically want a cheek-swab mail-in kit. Their TallyAge test measures DNA methylation and uses those patterns to estimate epigenetic age.
Elysium's Index is another saliva-based option. It analyzes methylation patterns and reports biological age, cumulative rate of aging, and ages for nine physiological systems.
If you're interested in more comprehensive methylation data, rather than simply getting an “epigenetic age” number, I'd look especially closely at TruDiagnostic. Its TruAge test says it analyzes more than 1 million methylation sites from a finger-prick sample and reports several established aging measures, including DunedinPACE.
There are two quite different things marketed as “methylation tests.”
Epigenetic methylation testing — measures methylation at many locations throughout your DNA and can be used for things like biological/epigenetic age, GrimAge, PhenoAge, DunedinPACE, etc.
Methylation genetics panels — look at a handful of inherited variants such as MTHFR, MTR, MTRR, COMT, etc. These are not measuring your actual current DNA-methylation pattern.
For example, IDLife's “Methylation Panel” uses a cheek swab but analyzes 16 genetic markers, so it belongs much more to the second category than the genome-wide epigenetic tests above.
If your goal is research-grade methylation profiling—e.g., getting the underlying CpG/IDAT data so you can calculate Horvath, GrimAge, PhenoAge, DunedinPACE, or other clocks yourself—that's a somewhat different shopping question. I can point you toward the companies that will actually give you the raw methylation data, rather than just a proprietary “biological age” score.
myDNAge utilizes Horvath's aging clock methodology via the myDNAge Epigenetic Clock About Page to sequence thousands of methylation loci from urine or blood samples.
If you can share whether you are looking to test your genetic variants (like MTHFR) or your biological/epigenetic age , I can help you narrow down which specific panel fits your goals.
