Data as of Oct 10, 2026Based on 7,492 AI responses
Reviewed by Dimitry Apollonsky ·
AKLIEF Cream (trifarotene 0.005%) is a prescription acne treatment indicated for topical management of acne vulgaris in patients 9 years and older, effective on the face, shoulders, chest, and back. It uses the retinoid trifarotene, which targets the RAR-γ receptor and is the first topical retinoid approved in 20 years, with a 12-week trial demonstrating safety and efficacy and some patients seeing results in as little as 2 weeks. Access is via dermatology providers, and savings programs may be available; common adverse reactions include application-site irritation and sun sensitivity, with precautions such as using a moisturizer, sunscreen, and avoiding waxing on treated skin.
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