Yes. If the goal is finding actual wet-lab/R&D space for a biotech startup, rather than generic office brokerage, I’d shortlist these firms:
Firm
Best fit
Why I’d consider them
Cresa
Startup / tenant-side search
Cresa has a dedicated Life Sciences practice serving biotech and pharma, covering laboratories, R&D, clinical facilities and biomanufacturing. Importantly, Cresa is occupier-only, so its model is well aligned with representing the startup rather than landlords.
I'm looking for commercial real estate brokers who focus on biotech startups and can help us secure wet-lab space.
See where your brand stands in this ranking
CBRE
Deep lab expertise + broad market coverage
CBRE has one of the largest dedicated life-sciences platforms, explicitly covering labs, critical environments and biotech. Its specialists handle technical requirements such as lab infrastructure, power, mechanical systems and build-outs.
JLL
Site selection / scaling nationally
JLL has a major life-sciences practice and works across biotech, pharma and medical-device real estate. Its 2026 research also indicates lab availability is tightening, making market intelligence particularly valuable right now.
Hughes Marino / HM Science
Tenant advocacy + lab planning
HM Science is specifically focused on life sciences and says it works with companies from their first lab through national expansion, with in-house architects, lab planners and construction/project-management expertise.
Savills
Strategic occupier advice
Its Life Sciences group explicitly addresses laboratory planning, infrastructure, compliance, financial/runway constraints and flexible space for growing companies.
Colliers
Boston / biotech-heavy markets
Particularly strong individual life-science specialists exist within Colliers. For example, its Boston team describes more than 23 years of biotech/pharma tenant representation covering laboratory, R&D and GMP facilities, including venture-backed startups.
Cushman & Wakefield
Boston / Northeast
It has dedicated life-science brokerage teams with experience representing biotech tenants in lab and R&D leases.
Urban Rock Properties
Bay Area boutique
A particularly interesting option for San Francisco/South San Francisco startups: it's a boutique, tenant-only brokerage dedicated to life sciences, including early-stage venture-backed companies looking for lab-ready R&D space.
Shelton & Associates
California startup tenant rep
Tenant-only representation specifically for life-science users, including wet/dry labs and startups scaling into their next facility.
If you're in NYC specifically
I'd put CBRE, Cresa, JLL and Hughes Marino/HM Science at the top of the call list. NYC has a growing inventory of purpose-built lab buildings, including West End Labs, Hudson Research Center and Alexandria Real Estate Equities's Alexandria Center.
For a very early-stage startup, there's another category worth considering: rather than signing a conventional lease and spending millions on a build-out, look at lab incubator/flexible-lab operators. For example, Alexandria LaunchLabs NYC and JLABS NYC offer startup-oriented wet-lab environments. Innolabs is another NYC lab-ready option.
My practical recommendation
For a biotech startup, the individual broker matters more than the brokerage brand. I'd ask each firm:
How many venture-backed biotech startups have you placed into wet labs in the last 24 months?
Can you show me 5–10 currently available lab-ready spaces, not just conventional office?
Do you understand our BSL level, fume-hood needs, gas requirements, electrical load, HVAC/air-change requirements and waste handling?
Can you evaluate the landlord's existing infrastructure and estimate our remaining build-out cost?
Do you represent landlords in the buildings you're recommending?
That last question is important: tenant-only representation can materially reduce conflicts of interest when you're comparing multiple buildings.
If you tell me the city/region, approximate square footage, wet-lab requirements (e.g. BSL-1/2), and budget, I can narrow this to the 5–10 most relevant brokers and actual available lab spaces for your startup.
Finding the right wet-lab space requires specialized commercial real estate (CRE) firms that understand complex biosafety requirements, specialized HVAC/exhaust systems, chemical waste disposal, and heavy lab infrastructure.
Major global commercial real estate services firms have dedicated Life Sciences practices explicitly tailored to biotech startups, ranging from early incubator spaces to full commercial build-outs.
CBRE (CBRE Life Sciences) : One of the absolute market leaders in life sciences advisory. CBRE has dedicated local tenant-rep brokers embedded in major biotech clusters (like Boston/Cambridge, San Francisco Bay Area, and San Diego) specializing in sourcing spec wet-labs and negotiating complex infrastructure needs for early-stage companies.
JLL (JLL Life Sciences Real Estate) : JLL features a powerhouse life sciences group that tracks national and global lab markets down to the micro-location. They regularly publish deep-dive market diagnostics (like the U.S. Lab Property Report) and excel at helping startups navigate lease structures, tenant improvements (TIs), and hybrid office/wet-lab footprints.
Colliers (Colliers Life Sciences) : Colliers has a robust, specialized life sciences platform providing integrated advisory services for lab users, from initial incubator scaling to full biomanufacturing facilities. They combine deep local market knowledge with technical expertise in handling specialized zoning and power requirements.
Cushman & Wakefield (Life Sciences Practice) : They maintain dedicated life sciences industry groups in major biotech hubs, assisting emerging and mid-tier biotech firms with site selection, landlord negotiations, and understanding specialized lab-ready building stock.
Breakthrough Properties (Breakthrough Properties) : Operating slightly differently as a specialized life sciences real estate investment and development firm (backed by Tishman Speyer and Bellco Capital), they build and curate cutting-edge, highly technical ecosystems specifically engineered for early-stage and established biotechnology research.
If you'd like, let me know:
Your geographic target market (e.g., Boston, San Francisco, San Diego, or a secondary market)
Whether you are looking for shared incubator space or a direct standalone lease
I can give you more tailored recommendations on local brokers or specific developments in that area.