At-home methylation testing

You can order mail-in methylation test kits directly from specialized wellness platforms, genetic testing companies, and online health retailers.

Depending on whether you are looking for genetic testing (like MTHFR gene variants) or functional metabolite testing (like homocysteine or overall methylation potential), several options are available:

• Genetic Methylation Panels (At-Home Swab) : Companies like Life Extension offer cheek-swab profiles to check common variants like MTHFR and COMT. Other brands like LifeDNA and PlexusDx provide similar trait-analysis kits online or through major retailers.[amazon.com](https://www.amazon.com/LifeDNA-Methylation-Analysis-Analyzes-Variants/dp/B0D4ZMTTFW)[[2](https://www.lifeextension.com/lab-testing/itemlc100045/mthfr-comt)](https://www.lifeextension.com/lab-testing/itemlc100045/mthfr-comt?srsltid=AU7gw4XUuMUjEJ4W7jC7wGXzjdxsJCxHwIS2ZMSPmF4ViiTTA3HRayny)[[3](https://www.target.com/p/plexusdx-genetic-methylation-test-kit-includes-mthfr-more-at-home-dna-test-clia-lab-health-test-95-reports/-/A-1002875527)](https://www.target.com/p/plexusdx-genetic-methylation-test-kit-includes-mthfr-more-at-home-dna-test-clia-lab-health-test-95-reports/-/A-1002875527)
• Functional & Metabolite Testing (At-Home Blood/Dried Urine) : If you want to measure real-time functional biomarkers (such as homocysteine or downstream metabolites), functional labs like Genova Diagnostics offer comprehensive panels that are typically ordered and drop-shipped through practitioner platforms like Rupa Health.[amazon.com](https://www.bodyspec.com/blog/post/genetic_methylation_test_2025_buyers_guide)
• Biological Age & Epigenetic Methylation : Companies like TruDiagnostic offer mail-in blood kits (TruAge) that measure DNA methylation patterns to estimate biological aging and related systemic health metrics.[amazon.com](https://www.bodyspec.com/blog/post/genetic_methylation_test_2025_buyers_guide)

Several companies offer at-home, mail-in kits that analyze DNA methylation —ranging from genetic pathway evaluations (such as MTHFR gene variations affecting methylation) to deep epigenetic sequencing that measures biological aging via DNA methylation clocks.

• EasyDNA offers a DNA Methylation Comprehensive Health Report ($279) utilizing a simple mouth swab to analyze genetic markers and predispositions linked to the body's methylation pathways.[easy-dna.com](https://easy-dna.com/dna-methylation-report/)
• empowerDX provides an At-Home MTHFR Gene Test focusing specifically on key mutations (like C677T and A1298C) involved in folate metabolism and the methylation cycle via cheek swab collection.[easy-dna.com](https://empowerdxlab.com/products/product/mthfr-gene-test)
• MosaicDX features a DNA Methylation Pathway Profile , which evaluates functional and genetic markers associated with the methylation network.[easy-dna.com](https://mosaicdx.com/test/dna-methylation-pathway-profile/)
• TruDiagnostic offers the TruAge Test ($499), a comprehensive blood-spot (finger-prick) test that analyzes over 1,000,000 DNA methylation sites to determine biological age, pace of aging (DunedinPACE), and specific organ system health metrics.[easy-dna.com](https://shop.trudiagnostic.com/products/truage-complete-epigenetic-collection)
• Elysium Health offers Index ($299), a saliva-based epigenetic test that maps DNA methylation patterns to estimate biological age and rates of aging across various bodily systems.[easy-dna.com](https://www.elysiumhealth.com/products/index)

Are you looking to analyze general wellness and biological aging (epigenetic clocks), or do you want to target specific genetic variants like MTHFR? Let me know so I can narrow down the best option for your goals.

If by “methylation testing” you mean DNA methylation / epigenetic testing, there are several services:

• TruDiagnostic TruAge — blood-spot test measuring 1M+ DNA methylation sites; reports biological age, pace of aging, and organ-system age. Currently listed at $499.TruDiagnostic™
• Generation Lab — at-home blood collection with a broad epigenetic/biological-aging report covering 460 biomarkers and 21 systems.Generation Lab
• AgelessRx TruMe — saliva-based DNA methylation test focused on biological age; results are advertised in 2–3 weeks.AgelessRx
• Kure Health AgeCode — combines genetic testing with epigenetic methylation testing and biological-age analysis; its complete package is listed at $1,799.Kure Health
• Stride — offers a genetic methylation test looking at methylation-related genes such as MTHFR. This is different from an epigenetic “biological age” test.Stride

Important distinction

“Methylation test” can mean three quite different things:

1. MTHFR/genetic methylation testing — looks for inherited variants affecting methylation pathways.
2. DNA/epigenetic methylation testing — measures methylation patterns across your DNA, often to estimate biological age or aging rate.
3. Functional methylation testing — blood markers such as homocysteine, B12, folate, etc., which assess aspects of methylation metabolism rather than DNA methylation itself.

If you tell me what you're trying to find out (e.g. MTHFR, biological age, methylation status, nutrition/B12/folate, or a comprehensive health test), I can narrow it down to the services that actually measure what you want.