ODesign in AI answers

ODesign is an all-atom generative world model for all-to-all biomolecular interaction design that unifies proteins, nucleic acids, and small molecules within a single framework. Researchers can specify epitopes on arbitrary targets and generate diverse binding partners with fine-grained control at the entity-, token-, and atom-level, using both rigid-target and co-design modes. It achieves superior throughput and performance across benchmarks, enables previously inaccessible designs such as protein-binding RNA/DNA aptamers and nucleic acid–binding ligands, and is available as a web server with open-source code.