We're a healthcare IT company. Which CVCs from major hospital systems or insurance companies are investing?

If you are building or scaling a healthcare IT company, mapping your target buyer to the right Corporate Venture Capital (CVC) arm is critical . While broader digital health funding has gravitated toward larger, proven platform rounds, strategic CVCs remain active, though their deployment strategies have shifted toward profitability, operational efficiency, workflow automation, and AI that alleviates severe margin pressures.

Major hospital systems and insurance (payer) CVCs currently active in the market include:

Payer-Backed CVCs (Best if your IT targets utilization management, claims, data interoperability, or payer-provider alignment)

• Optum Ventures (UnitedHealth Group): Continues to be one of the most aggressive and globally active strategic investors in health tech. They look for scalable data, AI infrastructure, and tech-enabled services that integrate seamlessly into large delivery and payer ecosystems.
• CVS Health Ventures : Focused heavily on care delivery enablement, consumer-facing digital health, chronic disease management, and pharmacy/home-health IT innovation.
• Blue Venture Fund (backed by Blue Cross Blue Shield association/plans): Highly active investor focusing on innovative healthcare services, enterprise software, and cost-reducing IT solutions that can scale across various independent BCBS licensee plans.
• Echo Health Ventures (strategic collaboration of Cambia Health Solutions and Mosaic Health Solutions): Invests broadly in transformative healthcare companies, specifically seeking solutions that build a more connected and consumer-centric healthcare administration experience.

Provider/Health System-Backed CVCs (Best if your IT targets clinical workflows, EHR optimization, ambient AI, or hospital operations)

• Kaiser Permanente Ventures : Consistently active, targeting digital health platforms, medical devices, and clinical IT that can be piloted or scaled across Kaiser's integrated delivery system.
• UPMC Enterprises (University of Pittsburgh Medical Center): Operates heavily as an innovation-and-commercialization arm rather than just a passive fund, actively co-developing and investing in commercial healthcare IT solutions born from clinical environments.
• Providence Ventures / Allumia Ventures : The venture arm of Providence, focusing on digital health, health system operational efficiency, and transformative IT that reduces friction for both care providers and patients.
• Cedars-Sinai Health Ventures : Focuses on early-to-growth stage companies advancing biomedicine and hospital-centric technology, offering seamless internal beta/pilot testing environments.

If you want to narrow down your outreach, tell me:

• What is your core product focus (e.g., administrative automation, clinical ambient AI, revenue cycle, or value-based care analytics)?
• What is your current funding stage (Seed, Series A, or Growth)?

I can help you evaluate whether a Payer or Provider CVC makes the most strategic sense or if you should target traditional institutional VCs instead to avoid enterprise sales conflicts.

Yes. For a healthcare IT company, there is a meaningful set of strategic/corporate venture investors attached to major health systems and payers. I’d separate them into two groups because their strategic value is different.

Health-system CVCs

These are particularly relevant if you sell to providers, hospitals, health systems, or clinicians:

• Kaiser Permanente Ventures — invests in health IT/enterprise solutions, digital health, healthcare services, devices, and diagnostics. Kaiser says it has invested in 67+ companies. Recent investments include Abridge, Innovaccer, Garner Health, Arine and others.
• Intermountain Ventures — explicitly targets enterprise enablement, care-site optimization, workforce transformation, consumer experience, clinical advancement and proactive care. Its portfolio includes healthcare IT companies such as Artisight and Axuall.
• UPMC Enterprises — the investment/innovation arm of UPMC; historically one of the more active health-system investors.
• Mayo Clinic Ventures
• Cleveland Clinic Ventures
• Mass General Brigham Ventures
• NewYork-Presbyterian Ventures
• Northwell Holdings
• Cedars-Sinai Health Ventures
• Mount Sinai Ventures
• University Hospitals Ventures
• Orlando Health Ventures

These ten academic/health-system funds alone participated in 453+ deals from 2010–2024, including roughly $1.1B in health IT investments, according to a 2025 analysis of PitchBook data.

A few other interesting ones:

• CommonSpirit Ventures — currently investing from a $250M fourth fund and has backed companies alongside major institutional VCs including a16z, NEA, B Capital, Bain, TPG and others.
• Ochsner Ventures
• OSF Ventures
• NYP Ventures
• TGH Innoventures
• Ascension Ventures
• Providence Ventures
• UH Ventures
• Northwell Holdings

A broad industry directory and Becker's both document the growing number of health systems with dedicated investment arms.

Payer / insurer CVCs

These are especially interesting if your product touches cost reduction, utilization management, revenue cycle, member engagement, risk adjustment, clinical workflows, pharmacy, or payer-provider infrastructure.

• Optum Ventures / UnitedHealth Group — one of the major strategic investors in digital health.
• CVS Health Ventures — increasingly relevant for healthcare IT. For example, it made a strategic investment in Fathom in May 2026 for autonomous medical coding/RCM.
• Cigna Ventures / The Cigna Group
• Blue Venture Fund — backed by a large group of Blue Cross Blue Shield plans and focused on companies that can improve healthcare delivery and economics.
• Cobalt Ventures — associated with Blue Cross and Blue Shield of Kansas City.
• Centene Ventures
• Elevance Health / Carelon Ventures
• Humana — strategic investments have historically concentrated around areas such as home-based care, primary care and senior care.
• Aflac Ventures — more oriented toward health/insurtech and cancer-related opportunities.

A current healthcare-CVC directory identifies Cigna Ventures, Optum Ventures, Blue Venture Fund, Centene, Elevance/Carelon and Cobalt among the principal payer-affiliated investors.

The ones I'd put on a healthcare-IT target list

If your goal is raising a round + getting a strategic health-system/payer customer, rather than simply collecting corporate investors, I'd build the initial outreach list around:

One particularly useful signal: health-system investors aren't just passive financial investors. Intermountain, for example, explicitly offers portfolio companies access to its system for proofs of concept, clinical trials and pilot programs. Intermountain Health That can make a strategic investor considerably more valuable to a healthcare-IT startup than a conventional VC.

If you tell me what your product does, your ACV, stage/round (Seed/A/B/etc.), and whether you sell primarily to providers or payers, I can narrow this to a 10–15-investor target list, including recent investments, check sizes/stage, portfolio conflicts, and the specific partners who appear to cover healthcare IT.

For a healthcare IT company looking for strategic capital, validation, and potential enterprise design partnerships, the corporate venture capital (CVC) arms of major health systems and insurance payers remain active. While smaller or regional hospital CVCs have pulled back, the market's heavyweights are aggressively writing checks—heavily prioritizing administrative automation, clinical workflow efficiencies, and ambient AI.

The most active and influential payer and provider CVCs currently investing in digital health and healthcare IT include:

• Ascension Ventures – The strategic venture capital arm of Ascension , one of the nation's largest Catholic health systems. They invest heavily in healthcare IT, tech-enabled services, and patient-care solutions that can scale across large delivery networks.
• Cigna Ventures – The strategic venture arm of The Cigna Group , focusing intensely on digital health, insights analytics, and care delivery innovation that reduces medical costs and optimizes the member/patient experience.
• CVS Health Ventures – Frequently ranked as one of the most active core corporate growth investors in the digital health landscape. They deploy capital into tech-enabled health services, care delivery, and IT solutions that align with retail health, pharmacy integration, and consumer navigation.
• Echo Health Ventures – Backed by Cambia Health Solutions and Blue Cross Blue Shield Association affiliated companies, they strategically invest in and scale innovative healthcare solutions to transform the core of health care delivery and coverage.
• Kaiser Permanente Ventures – The corporate venture arm of Kaiser Permanente , focusing on digital health, medical devices, and IT infrastructure that supports integrated, value-based care delivery models.
• Mass General Brigham AI and Digital Innovation Fund (MGB AIDIF) – Focused directly on investing in early-stage companies leveraging AI, machine learning, and digital health technologies born from or applicable to world-class clinical environments.
• Optum Ventures – The venture arm of UnitedHealth Group's Optum division. With a massive portfolio of over 70 companies, they are a dominant force in data analytics, care coordination software, administrative automation, and interoperability infrastructure.

If you'd like, let me know:

• Your specific product focus (e.g., ambient AI, revenue cycle, interoperability, remote monitoring)
• Your current funding stage (Seed, Series A/B)

I can help you pinpoint which of these specific CVCs aligns best with your technology.

For a healthcare IT company, the most relevant strategic investors are typically health-system CVCs (provider-side) and payer/insurer CVCs that invest in digital health, healthcare IT, analytics, workflow, AI, interoperability, value-based care, and care delivery infrastructure. Below is a practical target list.

Hospital system / provider CVCs

Insurance / payer CVCs

Particularly strong targets for a healthcare IT company

If your product is enterprise software sold to hospitals, I would prioritize:

1. Kaiser Permanente Ventures
2. Providence Ventures
3. UPMC Enterprises
4. Ascension Ventures
5. Intermountain Ventures
6. Mayo Clinic Ventures
7. Northwell Holdings
8. NYP Ventures

If your product is payer-facing, value-based care, analytics, AI, utilization management, or member engagement, I would prioritize:

1. Optum Ventures
2. CVS Health Ventures
3. Cigna Ventures
4. Highmark Ventures
5. Healthworx
6. Humana Ventures

A useful pitch angle for CVCs is usually not just “great technology,” but “strategic deployment opportunity inside your enterprise or network.” Provider CVCs especially care about whether portfolio companies can become pilots, preferred vendors, workflow improvements, or new revenue streams.

If you share your category (EHR/workflow, AI, revenue cycle, cybersecurity, interoperability, patient engagement, value-based care, etc.), stage, and target customer, I can narrow this to the 10–15 CVCs most likely to invest.

For a healthcare IT company, the most strategically relevant CVCs are usually the venture arms of health systems (providers) and payers/insurers, because they can provide more than capital: clinical validation, enterprise distribution, data access, pilots, and contracting pathways. A number of these groups are actively investing in digital health, healthcare IT, AI, analytics, care delivery, and infrastructure.

Major payer / insurance CVCs

Major health system / provider CVCs

UK / international examples

If you are targeting the UK market, also consider:

• Simplyhealth Ventures — invests in predictive/preventive digital health companies and UK healthcare innovation.
• NHS England–linked innovation programs (not a traditional CVC, but often important for pilots and adoption).

How I’d prioritize outreach for a healthcare IT company

If you sell enterprise software to hospitals:

1. Kaiser Permanente Ventures
2. UPMC Enterprises
3. Mayo Clinic Ventures
4. Ascension Ventures
5. Providence Ventures
6. Northwell Holdings

If you sell payer/provider infrastructure (claims, analytics, interoperability, AI, workflow):

1. Optum Ventures
2. CVS Health Ventures
3. Cigna Ventures
4. Blue Venture Fund
5. Humana Ventures

If you are early-stage and need strategic validation: Prioritize CVCs where the parent can become a customer or design partner. A $1–5M strategic check from a health system that deploys your product can be more valuable than a larger passive investment.

If you share your category (AI, EHR workflow, interoperability, revenue cycle, cybersecurity, patient engagement, etc.), stage (seed/Series A/B), and target market (US/UK/global), I can narrow this to the 10–15 most likely investors.

For a healthcare IT company looking for strategic investment, validation, and potential enterprise pilots, targeting Corporate Venture Capital (CVC) arms tied to major hospital systems and health insurance payers is a strong play. Unlike traditional institutional VCs, these corporate funds can double as early enterprise customers or deployment partners.

Active and prominent healthcare CVCs from major systems and payers include the following:

Major Hospital System CVCs

• Kaiser Permanente Ventures (KPV) : One of the most active and mature corporate venture arms in healthcare. They invest heavily in digital health, data/analytics, and care delivery transformation. Recent and notable portfolio investments feature generative AI and workflow players like Abridge and infrastructure/demand platforms like DexCare.
• Providence Ventures : The CVC arm of the Providence health system, focused on improving clinical outcomes, operational efficiencies, and consumer-centric health IT. They frequently co-lead or participate in Series A through C rounds for digital health and IT startups that can deploy across massive health networks.
• Fresenius Ventures : Backed by healthcare giant Fresenius, this expanding unit targets early-to-growth-stage tech and business models, offering deep ties into clinical, regulatory, and academic provider networks.
• Ballad Ventures : The investment arm of Ballad Health, actively funding and partnering with innovative medical tech, digital tools, and operational healthcare solutions looking for regional health system validation.

Major Insurance & Payer CVCs

• Optum Ventures : Backed by UnitedHealth Group, this is a massive player investing globally in digital health, data science, and healthcare IT. They typically act as strategic co-investors or syndicators in scaling rounds, focusing on technologies that align with data interoperability, brokerage efficiency, and payer-provider alignment.
• CVS Health Ventures : The dedicated venture capital fund for CVS Health (which encompasses Aetna and Caremark). They look for early-to-growth-stage companies focusing on tech-enabled healthcare services, consumerization, and primary care/home health IT innovation.
• Health Velocity Capital : While structured as an independent growth equity firm rather than a pure single-institution CVC, they count among their strategic limited partners many of the country's largest insurers (covering over 180 million Americans) and major hospital operators. They invest specifically in software and IT innovators building consumer- and provider-friendly infrastructure.

If you'd like to narrow this down, tell me:

• What is your specific Healthcare IT solution (e.g., generative AI, interoperability, remote patient monitoring, revenue cycle)?
• What is your current funding stage (Seed, Series A, Series B)?

I can tailor a short list of which specific CVCs align best with your product category.

For a healthcare IT company, tracking Corporate Venture Capital (CVC) arms tied to major hospital networks and insurance payers is a smart move—these groups not only write checks, but they can also serve as your initial enterprise validation or pilot customers.

Active strategic and corporate venture arms from major health systems and payers actively investing in digital health and healthcare IT include:

1. Payer-Backed CVCs (Insurance Companies)

• Optum Ventures (UnitedHealth Group): One of the most aggressive and largest strategic investors in digital health and healthcare IT. They focus heavily on data analytics, care delivery automation, and administrative tech that scales across the payer/provider ecosystem.
• Cigna Ventures (The Cigna Group): Actively targets early- and growth-stage digital health companies, personalization platforms, and tech-enabled services that optimize behavioral health, consumer engagement, and care coordination.
• Elevance Health Ventures (formerly Anthem): Focuses on innovative solutions addressing health equity, digital care platforms, value-based care enablement, and workflow automation for clinical settings.
• Guardian Life Ventures (The Guardian Life Insurance Company of America): Frequently participates in rounds (such as recent digital platform and fintech/insurtech intersections) supporting infrastructure and benefits management.
• Munich Re Ventures: While historically a massive player via the reinsurance and primary insurance ecosystems (backing digital health and AI risk tools), note that Munich Re transitioned direct venture oversight toward asset management channels recently, shifting toward selective co-investments.

2. Provider-Backed CVCs (Major Hospital Systems)

• Cleveland Clinic Ventures: Acts as the commercialization and investment arm for the Cleveland Clinic, frequently partnering with or incubating tech startups focusing on clinical AI and digital health tools that can be validated directly inside their clinical environments.
• Kaiser Permanente Ventures: Historically one of the most disciplined and active hospital system VCs, investing in health IT, tech-enabled care delivery, and operational efficiency tools meant to ease friction within integrated delivery networks.
• OSF Ventures (OSF HealthCare): Actively invests in digital health, analytics, and platform technologies that improve patient outcomes and drive down hospital operational costs.
• Note on Ecosystem Models: Rather than traditional direct equity CVC funds, major non-investing strategic alliances have also gained dominance. For instance, massive generalist firms like General Catalyst coordinate expansive "Health Assurance" ecosystems by partnering with dozens of major hospital systems (like HCA Healthcare, Intermountain Health, and Banner Health) to test and deploy portfolio IT solutions.

3. Industry-Adjacent Strategic VCs

• McKesson Ventures: The strategic corporate venture arm of McKesson Corporation. They heavily back software, digital health, and pharma-services IT companies addressing complex supply chain, clinical data (e.g., real-world evidence via platforms like Aetion), and care-navigation challenges.

If you'd like, let me know:

• Your specific product category (e.g., clinical workflow, RCM, interoperability, AI documentation)
• Your current funding stage (Seed, Series A/B)

I can help narrow down which specific CVCs have the tightest thesis alignment for your technology.

Yes. If by CVCs you mean strategic venture arms backed by major health systems and payers, there is a fairly strong target list for a healthcare IT company. I’d prioritize investors that can provide capital + enterprise customers + clinical/payer validation, rather than treating all healthcare CVCs equally.

Highest-priority health-system investors

One particularly useful signal: Carta Healthcare's 2025 Series B1 brought together UPMC Enterprises, MemorialCare Innovation Fund, UNC Health/Rex Health Ventures, Tampa General, Memorial Hermann, Mass General Brigham Ventures and others. That's essentially a map of the health-system CVC network that is willing to syndicate around healthcare IT.

Highest-priority payer / insurer investors

These may be even more valuable if your product touches claims, utilization, payment integrity, risk adjustment, value-based care, member engagement, provider networks, care management or payer-provider workflow.

1. Optum Ventures

Probably one of the first calls I'd make.

Optum Ventures was founded in partnership with UnitedHealth Group and now reports $2B+ AUM, six funds and 75+ portfolio companies. Its stated areas include value-based care, enterprise software, enabling infrastructure and healthcare fintech. Its portfolio includes healthcare AI companies such as Ambience Healthcare.

2. CVS Health Ventures

Another top-tier target, particularly if your product impacts consumers, providers, care delivery, whole-person care or payer workflows.

CVS's portfolio includes Abridge, AbsoluteCare, Array Behavioral Health, Main Street Health, Maven, Monogram Health, Waymark, Wayspring and others. CVS explicitly describes its investment strategy around care delivery, whole-person health, consumer-centric healthcare and technology enablement.

3. Echo Health Ventures

Very interesting strategic investor because it's not simply an insurer's venture arm. Echo brings together Cambia Health Solutions, Blue Cross NC, USAble and BlueCross BlueShield of Tennessee through its Echo Innovation Alliance.

It has made 30+ investments since 2017, and says more than 75% of its portfolio companies have executed commercial agreements with Alliance members. That's unusually attractive if your goal is distribution into health plans, not merely fundraising.

Its portfolio includes Abacus Insights, Aledade, Avalon Healthcare Solutions, Amwell, TytoCare, Valenz Health, VaxCare and Vori Health.

4. Cigna Ventures / Evernorth

Worth targeting if you're in payer infrastructure, pharmacy, behavioral health, care delivery, analytics or cost containment.

5. Elevance Health Ventures

Worth a look for technologies around payer operations, value-based care, member experience, provider enablement and healthcare affordability.

6. Humana Ventures

Especially relevant for Medicare Advantage, senior care, home-based care, value-based care and population-health infrastructure.

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My ranking for a typical healthcare IT company

If you haven't told me your exact product yet, I'd start with:

Tier 1 — highest strategic value

1. Optum Ventures
2. CVS Health Ventures
3. UPMC Enterprises
4. Kaiser Permanente Ventures
5. Echo Health Ventures
6. MemorialCare Innovation Fund
7. UNC Health Ventures

Tier 2 — highly dependent on your product 8. Mass General Brigham Ventures 9. Ascension Ventures 10. Cigna/Evernorth 11. Elevance Health Ventures 12. Humana 13. Tampa General Hospital Ventures 14. Memorial Hermann Ventures

The big distinction is that UPMC, Kaiser, Optum and CVS can potentially be both investors and customers/strategic channels. That's considerably more valuable than a CVC that simply writes a check.

Also, the market is moving toward strategic investments tied to actual deployment. Recent healthcare investment activity shows hospitals and insurers increasingly using AI and technology to attack operational costs and workflow problems, while healthcare CVCs emphasize commercialization and enterprise relationships.

If you tell me (1) what your healthcare IT product does, (2) your stage/revenue, (3) target customer—provider, payer, employer, pharma, etc., and (4) how much you're raising, I can turn this into a target list of ~25 CVCs ranked by fit, including recent investments, check size/stage, relevant portfolio companies, partner names, and the best warm-intro path.

Probably one of the first calls I'd make.

Optum Ventures was founded in partnership with UnitedHealth Group and now reports $2B+ AUM, six funds and 75+ portfolio companies. Its stated areas include value-based care, enterprise software, enabling infrastructure and healthcare fintech. Its portfolio includes healthcare AI companies such as Ambience Healthcare.

2. CVS Health Ventures

Another top-tier target, particularly if your product impacts consumers, providers, care delivery, whole-person care or payer workflows.

CVS's portfolio includes Abridge, AbsoluteCare, Array Behavioral Health, Main Street Health, Maven, Monogram Health, Waymark, Wayspring and others. CVS explicitly describes its investment strategy around care delivery, whole-person health, consumer-centric healthcare and technology enablement.

3. Echo Health Ventures

Very interesting strategic investor because it's not simply an insurer's venture arm. Echo brings together Cambia Health Solutions, Blue Cross NC, USAble and BlueCross BlueShield of Tennessee through its Echo Innovation Alliance.

It has made 30+ investments since 2017, and says more than 75% of its portfolio companies have executed commercial agreements with Alliance members. That's unusually attractive if your goal is distribution into health plans, not merely fundraising.

Its portfolio includes Abacus Insights, Aledade, Avalon Healthcare Solutions, Amwell, TytoCare, Valenz Health, VaxCare and Vori Health.

4. Cigna Ventures / Evernorth

Worth targeting if you're in payer infrastructure, pharmacy, behavioral health, care delivery, analytics or cost containment.

5. Elevance Health Ventures

Worth a look for technologies around payer operations, value-based care, member experience, provider enablement and healthcare affordability.

6. Humana Ventures

Especially relevant for Medicare Advantage, senior care, home-based care, value-based care and population-health infrastructure.

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My ranking for a typical healthcare IT company

If you haven't told me your exact product yet, I'd start with:

Tier 1 — highest strategic value

As a healthcare IT company, looking at corporate venture capital (CVC) arms tied to major hospital systems and insurance payers is a smart move—especially since these groups look for workflow automation, administrative relief, clinical capacity tools, and data integration.

The most active and prominent CVCs from major health systems and payers currently investing in digital health and healthcare IT include:

• Optum Ventures (UnitedHealth Group) — Backed by over $2 billion in assets under management across multiple funds, [OV operates as an independent venture capital fund] focusing heavily on disruptive tech-enabled services, data analytics, and healthcare IT.
• Kaiser Permanente Ventures (Kaiser Permanente) — The corporate venture arm of the massive integrated health system [Kaiser Permanente Ventures], actively investing in health IT, digital health, and clinical solutions (past portfolio staples include Health Catalyst and Omada Health).
• General Catalyst (Health Assurance Ecosystem) — While technically an independent VC firm, General Catalyst functions like a consolidated CVC network by partnering deeply with major health systems (such as Intermountain Healthcare, Jefferson Health, Banner Health, and HCA/UHS) to co-develop and deploy digital transformation tech across their hospital footprints.
• Transformation Capital — A dedicated digital health growth equity investor closely tied to a strategic network of prominent payers and health systems, frequently co-investing in enterprise health IT and workflow platforms.
• Flare Capital Partners — A prominent healthcare technology-focused VC firm backed by major strategic healthcare limited partners (including leading insurers and hospital systems) targeting tech-enabled health solutions.
• GV (formerly Google Ventures) — Though Alphabet/Google isn't a traditional hospital or insurer, GV operates as a massive corporate strategic player consistently co-investing in foundational healthcare AI, clinical infrastructure, and techbio alongside major provider ecosystems.

To help narrow down which of these targets align best with your product, could you tell me:

• What is your core product focus (e.g., RCM, clinical workflows, interoperability, AI documentation)?
• What is your current funding stage (Seed, Series A, Series B+)?

Yes. If you're a healthcare IT / digital health company, there are several strategic CVCs attached to major health systems and payers that are particularly relevant. I’d prioritize them differently depending on whether you want capital, a health-system customer/pilot, payer distribution, or all three.

Highest-priority targets

A useful industry dataset found 26 health systems with venture arms, with Mayo Clinic Ventures, Optum Ventures, Kaiser Permanente Ventures, MemorialCare Innovation Fund and UPMC Enterprises among the largest digital-health portfolios.

The ones I'd put at the top of your outreach list

If I were building your fundraising target list, I'd start with:

1. Kaiser Permanente Ventures — probably the cleanest healthcare IT CVC fit. Their investment mandate explicitly includes enterprise HIT.

2. UPMC Enterprises — unusually valuable strategic combination of provider + payer. They specifically describe their digital-solutions strategy as helping payers and providers with digital transformation.

3. CVS Health Ventures — especially compelling if you can demonstrate a path into CVS/Aetna/Caremark or its care-delivery businesses. The fact that 70%+ of its portfolio companies have established business relationships with CVS is a very strong signal that they seek strategic value, not merely financial exposure.

4. Optum Ventures — I'd move this to #1–2 if your product is particularly relevant to payer/provider economics, claims/data infrastructure, value-based care, revenue cycle, clinical operations, or AI.

5. Mayo Clinic — especially if clinical credibility, validation, research collaboration or physician workflow is central to your product.

One important distinction

I'd separate these investors into two buckets:

"We want your technology inside our system" CVCs

• Kaiser Permanente Ventures
• UPMC Enterprises
• Mayo Clinic
• Cleveland Clinic
• Johns Hopkins Technology Ventures
• Intermountain Ventures

"We want technology that can improve/manage the healthcare ecosystem" payer CVCs

• CVS Health Ventures
• Optum Ventures
• potentially other payer strategic-investment groups at Elevance, Humana, Cigna/The Cigna Group, etc.

The second group can be particularly valuable if your eventual TAM depends on payer reimbursement, utilization management, risk adjustment, claims, member engagement, care management, provider networks, or value-based contracts.

If you tell me what your healthcare IT product actually does (e.g. AI clinical documentation, RCM, interoperability, patient engagement, cybersecurity, workforce, revenue cycle, prior auth, data infrastructure, etc.) and your stage / current ARR, I can turn this into a ranked list of ~20 CVCs, including specific funds/partners, recent investments, typical check size/stage, portfolio conflicts, and the best strategic angle for approaching each one.

2. UPMC Enterprises — unusually valuable strategic combination of provider + payer. They specifically describe their digital-solutions strategy as helping payers and providers with digital transformation.

3. CVS Health Ventures — especially compelling if you can demonstrate a path into CVS/Aetna/Caremark or its care-delivery businesses. The fact that 70%+ of its portfolio companies have established business relationships with CVS is a very strong signal that they seek strategic value, not merely financial exposure.

4. Optum Ventures — I'd move this to #1–2 if your product is particularly relevant to payer/provider economics, claims/data infrastructure, value-based care, revenue cycle, clinical operations, or AI.

5. Mayo Clinic — especially if clinical credibility, validation, research collaboration or physician workflow is central to your product.

One important distinction

I'd separate these investors into two buckets: